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As monotherapy, cagrilintide produced 11.8% weight loss in the Phase 3 REDEFINE 1 trial at 68 weeks with the 2.4 mg dose
doi: 10.3389/fonc.2026.1834606 Received 19 March 2026 Revised 09 May 2026 Accepted 13 May 2026 Published 28 May 2026 Volume 16 - 2026 Edited by Fahui Liu, Xiamen University, China Reviewed by Armando Patrizio, Memorial Sloan Kettering Cancer Center, NY, United States Qiming Gong, Affiliated Hospital of Youjiang Medical University for Nationalities, China Hao Ling, Technical University of Munich, Germany Updates Copyright 2026 Kennedy, Thomas, DArcy, Odia, Kamdar, Pereira, Scarola, Miles, Frank, Taneja, Seetharamu and Mandal

The most common side effect is nausea , particularly when you first start the medication or increase the dose

The cost of a replacement vial is always less than the cost of weeks of reduced effectiveness from a degraded medication

This reduces hunger hormones like ghrelin and increases fullness sensations, leading naturally to lower calorie intake without severe hunger or fatigue
