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The result is a medication that helps people consume less and burn more energy while also balancing blood sugar and supporting breakdown of fat, which is why it has shown greater weight loss in early studies, says Rhodes

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Retrieved from Bezin, J., Gouverneur, A., Pnichon, M., et al

For tirzepatide (Zepbound) Jastreboff and colleagues reported in the New England Journal of Medicine in 2022 that at maximal doses, the percent of individuals reporting side effects were as follows: Nausea 31.0% Diarrhea 23.0% Vomiting 12.2% Constipation 11.7% Bettge and colleagues conducted a study published in Diabetes, Obesity, and Metabolism in 2017 that showed that individuals who were taking metformin while taking a GLP-1 were more likely to have side effects, especially nausea and vomiting
