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These molecules influence: GLP-1 and PYY secretion insulin sensitivity mitochondrial energy pathways fat oxidation inflammation modulation appetite and metabolic rhythm Scientific Reference 3: Koh et al., Cell (2016) This high-impact review explains SCFAs mechanistic roles in host physiology: signalling through receptors (e.g., FFAR2/FFAR3), epigenetic modulation, immunegut interactions, and metabolic regulation

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Report new or worsening symptoms promptly, especially early in treatment or after a strength change

These benefits extend to the pulmonary vasculature, where the agents have been shown to mitigate endothelial dysfunction, chronic inflammation, and adverse vascular remodelling, leading to associated improvements in pulmonary arteries [18]

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