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Diabetes Obes Metab 26(Suppl 4):1627 Xiang J, Qin L, Zhong J, Xia N, Liang Y (2023) GLP-1RA liraglutide and semaglutide improves Obesity-Induced muscle atrophy via SIRT1 pathway

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When GLP-1 medications are combined with other diabetes treatments, such as insulin or sulfonylureas, dose adjustments may be needed to lower the risk of hypoglycemia

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The safety profile showed modestly elevated rates of overall side effects and drug-attributable side effect in the efinopegdutide cohort relative to semaglutide, attributable predominantly to a higher frequency of gastrointestinal manifestations [52]

Glucagon receptor activation increases metabolic rate by stimulating thermogenesis in brown adipose tissue and enhancing mitochondrial activity in hepatocytes and skeletal muscle