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This method is also recognized for the treatment of obesity in Europe and the US

So that's just less than a year

Key points to remember: GLP-1 receptor agonists are not known to cause memory loss based on current evidence Research into potential neuroprotective benefits is ongoing but remains investigational Memory problems in people with diabetes have multiple potential causes that require proper medical assessment If you have concerns about memory or cognitive function whilst taking any medication, discuss them with your healthcare provider for appropriate evaluation and management If you suspect you have experienced an adverse effect from a GLP-1 receptor agonist or any other medication, you can report this through the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)

For more detailed titration context, see Janumet Dosage

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It is a large peptide-type molecule, and that size is exactly what makes it hard to deliver as a pill