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A well-known method of repressing transcription is methylation close to gene promoters

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Mild nausea during the first few days, a brief shift in bowel patterns, or slight abdominal discomfort is common

Slower gastric emptying : Food may move more slowly through the stomach, which can increase satiety but can also contribute to nausea, bloating, or constipation
However, it requires strict dosing, such as administration before breakfast under fasting conditions with minimal water intake