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14 mg in individuals with type 2 diabetes and overweight/obesity: Increasing the expectations to the efficacy of oral semaglutide 50 mg once daily in obesity without type 2 diabetes (for some currently unclear reason(s), body weight-lowering medications tend to have smaller effects in people with type 2 diabetes)

Future research should prioritize human trials, bioavailability optimization, and synergistic formulations to harness the full therapeutic potential of plant-derived GLP-1 agonists in metabolic disorders.

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