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It is currently unclear if the resistance to GLP-1 is primarily due to impaired receptor expression, reduced signaling in the gut-brain axis and/or intestinal dysbiosis

Oral Wegovy Clinical Trial Results: OASIS 4 The FDA approval was based on the OASIS 4 clinical triala 64-week study examining oral semaglutide 25mg in 307 adults with obesity

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This is particularly important for individuals with diabetes or those predisposed to insulin resistance

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- Supports appetite decrease for better management
