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The delayed translation of GLP-1 illustrates a critical principle: biological validity alone is insufficient for therapeutic success

J Endocrinol Investig

Both gastroparesis and intestinal blockage, which has also been linked to these GLP-1 drugs, can be fatal if not treated (likely including surgery)

As nearly all former GLP-1 users will attest, the weight just bounces right back

An obvious increase in risk of aortic inflammation and atherosclerosis was seen in GIP- knocked out mice, despite maintained glucose homeostasis and reduced weight gain

Clinical Experiences with GLP1 Agonists in a Weight Management Program In the context of a weight management program, we present a series of case studies that illustrate the potential for GLP-1 agonists to trigger or exacerbate restrictive eating behaviors