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Efficacy determination was based on the effect of WEGOVY injection on resolution of steatohepatitis without worsening of liver fibrosis and on at least one stage improvement in liver fibrosis without worsening of steatohepatitis, on post-baseline liver biopsies collected at 72 weeks

doi: 10.1056/NEJMcibr2409089

Biomarkers That Strengthen Medical Necessity Documentation Beyond HbA1c, specific biomarkers indicate cardiometabolic dysfunction and support insurance approval arguments

Any estimated increase in relative risk must be interpreted in the context of the low overall incidence of NAION

Gastrointestinal problems are common initially, but starting with a lower dose and gradually increasing it might alleviate these side effects
