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However, these analyses often included smaller trials with shorter follow-up, which may increase heterogeneity and reduce reliability regarding long-term cardiovascular and safety outcomes

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There is enormous exuberance about starting GLP-1 drugs, but not nearly enough attention to what happens when people stop, said senior author Ziyad Al-Aly, MD, a WashU Medicine clinical epidemiologist and chief of the Research and Development Service at the VA Saint Louis Health Care System

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In terms of systematic literature review, only three studies were included

Meaningful weight loss and improvement in conditions like type 2 diabetes, sleep apnea and high blood pressure More energy for work, family and movement Long-term support for weight maintenance when paired with healthy habits Within weeks, many people need fewer medications, sleep better and move with less pain, says Dr