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CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration

Potential interactions, synergistic effects, or adverse reactions may occur, necessitating close monitoring and adjustment of supplementation regimens to optimize safety and efficacy

While the mechanisms by which GLP-1 and GLP-1RAs affect intestinal motility remain to be defined, they appear to inhibit gastrointestinal motor function through both parasympathetic (vagal) afferents and direct central nervous stimulation (85-87)