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these experiments also showed that although glucose production was inhibited initially, plasma glucose concentrations only fell by 0.51.0 mmol/L in spite of prolonged infusion, because the insulinotropic effect of GLP-1 disappeared as glucose concentrations fell, demonstrating the glucose dependency of these actions

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Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients

Key risks include amplified gastrointestinal symptoms (nausea, vomiting), worsening nutritional deficiencies, increased gallbladder disease risk, and potential hypoglycaemia in patients taking diabetes medications

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Although these investigations shed light on some valuable concrete evidence, they were largely based on secondary research