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doi: 10.1097/AOG.0000000000004723

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Previous serious hypersensitivity reactions, current pregnancy (especially for weight-loss indications), active pancreatitis and severe gastroparesis generally contraindicate use

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The truth is that semaglutide's half-life of approximately seven days means the injection time matters far less than consistent weekly dosingbut individual factors like sleep quality, meal timing, and circadian metabolism can influence how well nighttime dosing works for you