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While these medications can impact the digestive system, they do not require a gallbladder to function effectively, and many patients find them helpful for managing weight gain that often follows surgery

10.1038/nrgastro.2015.204 [DOI] [PubMed] [Google Scholar] Weina H., Yuhu N., Christian H., Birong L., Feiyu S., Le W

Tirzepatide, a novel twincretin targeting both GLP-1 and GIP receptors, has demonstrated efficacy for treating T2DM in the SURPASS clinical trial program [168] and overweight/obesity in the SURMOUNT studies [169]

Dietary modifications , proper timing of doses , and gradual escalation all help minimize gastrointestinal distress