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11 This adverse effect may be related to GLP-1 R activation in the CNS, which can influence cerebrovascular tone and regional blood flow, potentially resulting in cerebral vasodilatation and headaches due to mechanical strain on pain-sensitive structures

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Real-world observational studies examining clinical data have not identified consistent patterns of increased rates of general vision problems associated with GLP-1 use, though most studies were not specifically designed to detect rare ocular events

The FDA initiated the review in mid-2023 after reports surfaced of suicidal ideation among some individuals using GLP-1 medications for weight loss

Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI) (Beyotime, China) at RT for 10 min

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