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Efficacy and safety of once-weekly semaglutide 1.0mg vs once-daily liraglutide 1.2mg as add-on to 1-3 oral antidiabetic drugs in subjects with type 2 diabetes (sustain 10)

These in vivo data continue to support our belief that our differentiated antibody approach can potentially provide meaningful efficacy without the challenge current small molecule CB1 inhibitors facebrain exposure that can cause unwanted neuropsychiatric side effects. Figure 1 - DIO model to interrogate combination of nimacimab and tirzepatide New In Vitro Data Characterizes Differentiated Potency Characteristics Skye also shared new in vitro potency data demonstrating that nimacimabs non-competitive allosteric binding to CB1 provides for a differentiated and potentially advantageous mechanism of inhibition versus small molecules like monlunabant, which must compete with CB1 agonists

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