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What the Evidence Says About GLP-1 Medications: An Honest Summary GLP-1 receptor agonists work through a mechanism that's been well-characterized in peer-reviewed medical literature and forms the basis for the clinical evidence that's made this drug class one of the most discussed pharmacological developments in obesity medicine in a generation

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GLP-1 RAs may inhibit retinal neurodegeneration and reduce proinflammatory processes, which could protect against diabetic retinopathy progression

Symptoms may temporarily improve after a bowel movement but tend to return

However, Sheehan et al