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5.13 Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Multiorgan Hypersensitivity Reactions Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), also known as multiorgan hypersensitivity has been reported in patients taking topiramate

Cloudiness, discoloration, particles, or unusual odor are red flags requiring immediate replacement

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Hold, dont leap

Tirzepatide is showing a similar impact but is not yet FDA approved for this indication

Supplementation with magnesium glycinate (200 to 400 mg at bedtime) serves double duty