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I would also argue that estrogen hormone therapy, progesterone, testosterone, when indicated, is going to have a synergistic effect with these GLP ones

The role of evidence in the rise and fall of insulin coma therapy', History of Psychiatry , 33/1, 65-71

Researchers continue to investigate how coordinated receptor activity may influence signaling mechanisms, peptide interactions, and downstream biological pathways under controlled research conditions

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Pathways implicated in addiction also contribute to pathological overeating and obesity, they write