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Loss of certain subpopulations of vagal nerves shows similar results, where selective denervation of CCK receptor-containing vagal afferents abolished the satiating effects of GLP-1 and CCK, as well as feeding-induced c-fos expression in the NTS [90]
These medications, primarily prescribed for type 2 diabetes and weight loss, are now at the center of thousands of claims alleging severe gastrointestinal injuries
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