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Another two longer-acting analogs, glepaglutide and apraglutide, are currently undergoing phase III clinical trials
Short-acting GLP-1 RAs, exenatide and lixisenatide, are associated with a transient (112 h) mean placebo- and baseline-adjusted 24-h HR increase of 13 beats per minute (bpm)
Those are deflation, deep wrinkles, dehydration, and density loss
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The gastrointestinal side effects of GLP-1 drugs are mediated by the brain, not the gut
