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Clinical Trial Evidence for Retatrutide The most widely referenced data comes from a Phase 2 trial published in the New England Journal of Medicine in 2023
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Clinical trial data shows that most patients experience peak digestive slowness in weeks 2-4 after starting or increasing their dose, with symptoms often improving by week 8 as your body adapts

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This was driven predominantly by reductions in nonfatal myocardial infarction, with consistent benefits observed across subgroups regardless of baseline use of other cardiovascular medications like SGLT2 inhibitors