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Of particular interest to researchers is Retatrutides triple agonist mechanism, which published Phase 2 data suggests produces distinct and potentially additive metabolic effects compared to both selective GLP-1 agonists and dual GIP/GLP-1 agonists

While chills are not listed as a direct side effect of Ozempic, they may occur due to these indirect effects of weight loss and metabolic changes

H., Preckel, B., & Hermanides, J

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Burak Altintas, MD, an orthopedist with UTMB, who was not involved in this study, further highlighted the following limitations of the research: The limitations include retrospective design and likely residual confounding despite matching as fracture risk is influenced by many variables that are not reported [] Further, the comparison group is heterogeneous, combining another GLP-1 receptor agonist (dulaglutide) with two mechanistically different weight-loss medications