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In addition, some putative effects of GLP-1RAs on cognitive and mental health symptoms may not require direct activity in the CNS, but rather be mediated by the actions that these medications express in the periphery across immune, endocrinemetabolic and gutbrain axis mechanisms (Fig

Sources: Harvard Health Publishing

Dan Henderson, a primary care and obesity medicine physician in Boston, three main trends drive the GLP-1 explosion: First, the newer generation of GLP-1s are incredibly effective at supporting weight loss, and patients and providers love having such a powerful weapon against obesity

Tirzepatide might cause stomach issues and a bit of low blood sugar

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However, there is no clinical evidence supporting this claim in the context of tirzepatide use