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In the case of glucagon, greater glucagon potency would lead to greater energy expenditure and suppression of food intake, but there seems to be a threshold beyond which glucose control worsens despite weight loss

Satiety and Nausea: Both activate satiety centers in the hypothalamus, which may contribute to the nausea commonly seen during drug initiation or dose escalation
Research shows that GLP-1 medications do not directly bind to or metabolize lamotrigine, so there is no chemical interaction at the liver or kidney level

Experts Recommend Healthy Lifestyle Changes Alongside GLP-1 Drug Use

Note: GLP-1 RAs differ in their dosing frequency (daily or weekly, depending on the agent)

doi:10.1111/dom.14280 18
