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Detailed Category Analysis# Mechanism of Action# MET-097i : Fully-biased GLP-1 receptor agonist utilizing HALO platform technology for ultra-long half-life (~380 hours)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Heart failure with preserved ejection fraction

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doi: 10.1038/s41574-018-0016-2 20 CampbellJEDruckerDJ

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17 The patient baseline characteristics are generally similar among the trials and are summarized in Supplementary Table 1 (339.9KB, pdf) (available in online article)

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In neurons, it involves the activation of PI3K/Akt signaling pathway, inhibition of GSK-3, reducing tau phosphorylation, promotion of mitochondrial biogenesis, activation of the Bcl-2 family proteins, and inhibiting apoptosis

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Energy Delivery The Sofwave handpiece glides across the skin, delivering ultrasound energy

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