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A meta-analysis of cardiovascular outcome in patients with long disease duration including Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE), and Veterans Affairs Diabetes Trial (VADT) suggested that in these populations the reduction of ~1% in A1C is associated with a 15% relative reduction in nonfatal myocardial infarction (4)

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PIONEER-2 showed it was superior to empagliflozin (an SGLT2 inhibitor) in reducing A1c

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4 Interestingly, the AACE/ACE algorithm additionally makes non-insulin recommendations for patients who are optimized on basal insulin and require additional postprandial glycemic control