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And so that may change

In its phase 2 trial, retatrutide improved blood pressure, lipids, and glycemia as secondary endpoints, consistent with its weight effect though these are early, secondary findings in a relatively small study

Discontinuation is commonly associated with appetite return and weight regain

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In addition, GLP-1R overexpression results in improved cognitive function in mice and GLP-1R knockout severely impairs cognitive ability (5, 117, 118)

In addition to macrophages, human neutrophils and eosinophils have also been shown to express GLP-1R and GLP-1 signaling significantly decreased the expression of eosinophil-surface activation markers along with a decrease in the production of IL-4, IL-8 and IL-13 (39)