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Second, some baseline characteristics, such as included population, duration of study, background therapies and quality of studies are different across included RCTs which are particularly relevant as cardiometabolic effects of GLP-1RAs may differ when these agents are added to insulin, metformin, sulfonylureas, DDP-4 inhibitors and SGLT-2 inhibitors

How Tirzepatides Dual Mechanism Works: GIP (Glucose-Dependent Insulinotropic Polypeptide) Adds: Tirzepatide activates both GLP-1 and GIP receptors