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Description
Barrier 3: first-pass metabolism

In APP/PS1 transgenic mice, (D-Ser2)Oxm, a dual GLP-1 and Gcg receptor agonist, notably improves spatial memory and synaptic plasticity, reduces A plaque deposition in the hippocampus, and modulates the PI3K/AKT1/GSK3 signaling pathway [84]

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