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Some signs of reduced effectiveness include: Breakthrough Bleeding : This is light bleeding or spotting that can happen between periods

In dedicated renal outcome trials, SGLT2 inhibitors significantly reduced the risk of composite renal adverse events, including the development of ESKD or renal replacement therapy, which led to the positioning of SGLT2 inhibitors as the mainstay of chronic kidney disease management

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Wegovy cardiovascular risk reduction In March 2024, the FDA approved Wegovy for reducing the risk of major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) in adults with established cardiovascular disease and overweight or obesity