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Ongoing studies are evaluating cardiovascular outcomes with tirzepatide in populations with overweight/obesity and T2D (SURPASS-CVOT) and in those with obesity but without diabetes (SURMOUNT-MMO) [28, 29]

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However, their expression in various tissues, albeit in smaller quantities, accounts for the multi-systemic effects of GLP-1RAs

doi: 10.1186/s12974-018-1370-7 [DOI] [PMC free article] [PubMed] [Google Scholar] 126

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Lower glucagon levels also contribute to a lower overall appetite
