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While norepinephrine seemingly inhibits GLP-1 secretion via its action on -adrenergic receptors, its secretion is stimulated by isoproterenol, and this effect can be blocked by co-infusion of the -adrenergic receptor antagonist propanolol [337]

Although these data are necessary and informative, it will be critical to better understand whether analogous effects are observed within a narrower window of changing leptin levels, as may occur during alterations of energy state or development in fed versus fasted states (RamosLobo et al., 2019)

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Understanding their differences can help you and your provider determine which option may be best suited for your weight loss goals

When patients follow the fasting window, water limits, and timing guidelines carefully, they give the drug the opportunity to work at its full potential