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Some highly sensitive individualsoften referred to as fast respondersdo report a dramatic drop in their cravings and a noticeable loss of mental food noise within the first 24 to 48 hours

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[10] reported that metformin acutely and selectively increased plasma levels of GLP-1 in mice, even in the absence of concomitant oral glucose administration, while it did not increase plasma levels of the other incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), or, curiously, peptide YY, a gastrointestinal hormone co-localised with GLP-1 in L cells

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Bryant RV, Schultz CG, Ooi S, et al

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