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PF-06882961 is orally bioavailable and efficacious for lowering glucose and food intake in monkeys The pharmacokinetics of PF-06882961 were examined in rats and monkeys after intravenous (IV) and oral administration (Fig 5A, Table S7)

Degradation was slower than for hGLP-1 but clearly measurable, with less than 50% uncleaved pGLP-1 and eGLP-1 remaining after 11 hours of incubation (Table 1)

She also learned that where she injected the medication mattered

Approval (2017) Ozempic: Frequently Asked Questions | Ozempic (semaglutide) injection Wegovy: How to Use the Wegovy Pen | Wegovy (semaglutide) Injection 2.4 mg Influence of Buffering Capacity, pH, and Temperature on the Stability of Semaglutide: A Preformulation Study Once-Weekly Semaglutide in Adults With Overweight or Obesity (March 2021) Oral Semaglutide Versus Subcutaneous Liraglutide And Placebo In Type 2 Diabetes (PIONEER 4): A Randomised, Double-Blind, Phase 3a Trial

Digestive system: increased satiety GLP-1 RAs increase satiety by inhibiting gastrointestinal motility [7]

Obviously we do have 20 years, as you said, although it was with lower doses with individuals with type 2 diabetes using that as a group to compare to we have not seen any development of concerns that have emerged