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2022 Grade B recommendation), (2) the proposed mechanism overlap between what GLP-1 medications appear to suppress and what energy-based devices stimulate, and (3) the Catalfamo 2025 case series (PMID 40806889) showing in-clinic bipolar RF is effective for the skin laxity component of Ozempic face, which suggests the mechanism is RF-responsive even if the at-home device delivers less energy than a clinical equivalent

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The limitation: More meds means more opportunities for side effects, and because trevogrumab and garetosmab are monoclonal antibodies, they could be costly and complicated to administer

doi: Wilding JPH, Batterham RL, Davies M, et al

Andreasen CR, et al

Diabetes Care 27, 20672073