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Although most current studies are confounded by metabolic comorbidities, recent findings by Nicolau et al 5 begin to address this gap by evaluating the effects of GLP-1 RAs in metabolically healthy patients, providing preliminary support for a direct immunologic mechanism

Weight trajectories and metabolic markers should serve as follow-up triggers to prevent acute fluctuations during sensitive reproductive windows

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They arent recommended for people with a personal or family history of medullary thyroid carcinoma or MEN-2 syndrome

E-values were employed to determine the likelihood of unmeasured confounding

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