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Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial

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[00:18:26] Emily Field: Research suggests that without intervention, adults roughly lose about three to 8% of their muscle mass per decade, and that rate of weight loss tends to accelerate after age 60, especially if someone is sedentary or not engaging in resistance training

Margulies KB, Anstrom KJ, Hernandez AF, Redfield MM, Shah MR, Braunwald E, Cappola TP

All participants described reduced appetite due to increased satiety

Frontiers in Pharmacology, 15 , 1416985