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Ania Jastreboff , MD, PHD, is an adult and pediatric endocrinologist at the Yale School of Medicine in New Haven, Connecticut

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Although metformin increased GLP-1R level, exendin (939) or GLP-1R siRNA did not attenuate the protective effects of metformin in PA-impaired HUVECs, suggesting that metformin per se could not exert protective effects via GLP-1R, instead, metformin upregulated GLP-1R to enhance the protective effects of liraglutide on endothelial function

5 GI events like nausea, diarrhea, constipation, vomiting, and dyspepsia were the most frequently reported adverse effects

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