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GLP-1 receptor activation also suppresses glucagon secretion, slows gastric emptying, and reduces appetite through central nervous system pathways that promote satiety
In fact, about 30 million people in the U.S

Individuals with obesity and T2D present leptin resistance and higher circulating levels that drastically reduce the signaling of leptin in POMC neurons and the anorexigenic activity in the ARC [127,128]

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Several lines of evidence suggest that additional mechanisms might contribute to both early and sustained metabolic improvements after bariatric surgery
