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Or placebo-treated patients in clinical trials may have different baseline risk profiles than real-world patients on alternative medications

The choice between injectable forms also extends to oral versus injectable tirzepatide , with newer sublingual drops and orally disintegrating tablets entering the market

With orforglipron offering additional advantages such as the elimination of strict pre-dosing requirements, potential lower cost, and easier storage, it will be important to see whether these features lead to even greater adherence, says Priya Jaisinghani, a diabetes and obesity medicine specialist at NYU Langone

McGuire J

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