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Many trials were designed to explore cardiovascular safety or benefit using SGLT2i molecules, including empagliflozin, dapagliflozin, canagliflozin, and ertugliflozin, which greatly differ in their characteristics, including the number of participants, study duration, the inclusion of patients with HF or renal disease, HF characterized by reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF), and associated comorbidities or risk factors, clearly implying differences in the risk and rate of cardiovascular or renal events recorded during the investigations [2]

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The 4 week interval represents the optimal balance between rapid therapeutic escalation and physiological adaptation time

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Recalls & Warnings January 21, 2018 Joint Supplement Recalled for Salmonella Risk On January 21, 2018, Arthri-D, LLC announced a recall of its joint pain supplement, Arthri-D (120 count), due to possible Salmonella contamination