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Overall, this resulted in a 53% reduction in integrated incremental GLP-1 concentrations (AUC above baseline) in type 2 diabetic patients relative to healthy controls and a 19% reduction in the total AUC (above 0 pmol/l)
doi: 10.1038/sj.emboj.7600244

Role of prohormone convertases in the tissue-specific processing of proglucagon

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Despite the exciting therapeutic potential of these multi-receptor agonists, the causal effects of activating the GLP-1R, GIPR, and GCGR pathwaysboth individually and in combinationon MASLD and its multi-organ complications are not yet clearly established [21, 23, 24]
