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Although dual and triagonist medications have so far exhibited side effects comparable to those of GLP- 1 receptor monoagonists in human trials, these preclinical findings imply that GIP receptor agonism may be the secret to obtaining the weight loss advantages of incretin agonism with less severe side effects

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Both tirzepatide and retatrutide have shown safety in clinical trials, but long-term effects are still being studied

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Watching for gastrointestinal side effects that could affect hydration