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Considering its broad sideeffect profile, its efficacy and safety in individuals without diabetes mellitus (DM) are yet to be fully understood

Tirzepatide significantly reduced body weight and improved glucose tolerance in HFD-fed mice without altering -cell mass, proliferation, or apoptosis

Our results demonstrate that AI-driven design can generate potent anti-GIPR antibodies with favourable in vivo efficacy, supporting further development of GIPR antagonist for obesity and related metabolic disorders

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