no more compounding glp 1 drugs FDA Cracks Down on Compounded GLP-1 | Paul Healy 💊🧬 posted on the topic Patients struggle as compounded GLP-1

GLP-1R works through the combination of the endogenous ligand Glucagon-like peptide-1 (GLP-1) or exogenous agonists, which activate multiple intracellular signaling pathways that enhance insulin secretion, inhibit glucagon secretion, protect -cells from apoptosis, delay gastric emptying and increase satiety

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These side effects may affect treatment adherence and long-term persistence

Mozaffarian D et al

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GLP-1 medications also carry an FDA black box warning for risk of thyroid C-cell tumors, and should not be used by patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 (MEN2)