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Several animal studies and preliminary human trials have suggested that allulose may influence postprandial glucose responses and potentially affect GLP-1 secretion, though the evidence base remains limited and requires further validation

A recent study further demonstrated that the suppression of hepatic glucose production, measured via the clamp technique using tracer glucose, was accompanied by a reduction in glucagon levels and increased insulin secretion in subjects with type 2 diabetes administered 100 mg of vildagliptin (55)

doi: 10.1001/jama.2024.0318

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