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They might not only be beneficial for GLP1R LoF carriers but also for obese and diabetics patients that are either resistant to current GLP1R agonists treatments or are suffering from serious adverse effects

For this, the Patient Health Questionnaire-9 (PHQ-9) [100] could be used, which consists of 9 items
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Therefore, a more gradual dose escalation will likely decrease the severity and frequency of those specific side effects [49]

Studies indicate that SHBG can be useful as a marker for a higher risk of PCOS [66]

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