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We also consider the effect of these molecules on other obesity-related complications [glycaemia in people with T2D and on liver fat content in people with MASLD/metabolic dysfunction-associated steatohepatitis (MASH, previously known as non-alcoholic steatohepatitis)] and we discuss the potential clinical implications and challenges that the new era in obesity pharmacotherapy will bring

The data shows that 18% of Black adults have taken these medications, making them more likely to have used them than White adults (10%), and Hispanic adults (13%)

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Obesity has many metabolic consequences, such as type 2 diabetes mellitus (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), hypercholesterolemia, chronic kidney disease (CKD), cardiovascular disease, and an increased risk of certain types of cancer [2, 3]

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MASLD/Fatty Liver Disease Given the remarkable liver fat clearance data, individuals with diagnosed metabolic liver disease may see outsized benefits from retatrutide compared to other options.